Yes, Norton works.... but, it tends to be a resource hog, which is my major malfunction with it. Especially some of the higher end versions.... with twelve separate processes that start with windows. MSE is a very light footprint, ONE process, same for defender. And neither one tries to do stuff that compromises what you actually WANT to do. I HATE the a/v's that demand to scan EVERY file the O/S tries to access..... Talk about a performance killer.....
I don't run any A/V on my personal machine either. Haven't for years. I simply don't need one. I don't go to sites that are famous for handing out malware, and I run an adblocker, as ads are the favorite medium for malware transport at this point. If a site won't let me visit unless I turn it off, I don't visit.
Most of the machines at work are win 10. We have a couple machines running 7, one machine with XP....... (only on when needed) we even still have a win 98 machine.... but, I don't think we have even turned that one in for a couple years. And, of course, the linux server...... (for NAS duties, DHCP, and PXE boot.)