When I play either SLE or SSE and reload my game after I did something, anything it doesn't matter other than I was running, then I decided to re-load my game I can't run with my PC anymore in-game. Sometimes I can re-load my game 1-2 times before I can't run and this only happen in Skyrim.
I suspect, now this is my theory, that a SSD handles data information differently in comparison to a SATA and there is one thing, from I understand, a SSD might not have is a cache memory while a SATA has a cache memory.
So when I re-load my game in Skyrim the data from the Skyrim.ini and/or SkyrimPrefs.ini isn't properly saved on a SSD while it is properly saved on a SATA.